解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Post‑transcriptional mechanisms are an important approach in the treatment of cancer, and may also be hijacked by tumor cells to help adapt to the local microenvironment. Filamin B (FLNB), an actin‑binding protein that provides crucial scaffolds for cell motility and signaling, has also been identified as an RNA‑bindi...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2020.7532
更新日期:2020-05-01 00:00:00
abstract::Inflammasomes can identify endogenous danger signals as an inflammatory immune response. As the most common inflammasome, the NLR pyrin family domain containing 3 (NLRP3) inflammasome is associated with the pathogenesis of different tumors. However, the function of the NLRP3 inflammasome in esophageal cancer (EC) has ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2020.7493
更新日期:2020-04-01 00:00:00
abstract::Glioblastoma (GBM) is the most common type of primary central nervous system tumor in adults, which has high mortality and morbidity rates, and short survival time, namely <15 months after the diagnosis and application of standard therapy, which includes surgery, radiation therapy and chemotherapy; thus, novel therape...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2020.7472
更新日期:2020-03-01 00:00:00
abstract::The efficacy of chemotherapy for hepatocellular carcinoma (HCC) remains unsatisfactory, primarily due to inherent self‑defense mechanisms (e.g., mitophagy and autophagy). In the present study, we aimed to explore the pro‑apoptotic effects of targeting mitophagy to potentiate the efficacy of chemotherapy for HCC. HCC c...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2020.7476
更新日期:2020-03-01 00:00:00
abstract::Glioblastoma multiforme (GBM) is the most aggressive human brain cancer. Little is known regarding how these cells adapt to the harsh tumor microenvironment, and consequently survive and resist various treatments. Myoglobin (MB), the oxygen‑binding hemoprotein, has been shown to be ectopically expressed in different h...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2020.7479
更新日期:2020-03-01 00:00:00
abstract::Glucocorticoids (GCs) are known potent clinical drugs, however, their mode of action is still complex and debatable. Macrophages are the most important target of GCs and play a key role in tumor immunity in vivo, but their relationship is also controversial. In the present study, the lentivirus system was used to over...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7434
更新日期:2020-02-01 00:00:00
abstract::The present study aimed to explore the relationship between the efficacy of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR‑TKIs) and the expression of the cancer stem cell (CSC)‑related markers. Specimens of 72 cases of lung adenocarcinoma with significantly different therapeutic effects of the firs...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7454
更新日期:2020-02-01 00:00:00
abstract::Alterations in DNA methylation have a central role in the development and outcome of most human malignancies. Non‑small cell lung cancer (NSCLC), the most common lung cancer, leads to the largest number of cancer‑related deaths worldwide. FBJ murine osteosarcoma viral oncogene homolog B (FOSB) is a key component of th...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7431
更新日期:2020-02-01 00:00:00
abstract::Acute lymphoblastic leukemia (ALL) is a malignant hematological disease. Tanshinone IIA (Tan IIA) has antitumor activity in vitro and in vivo. The aim of the present study was to investigate the effects of Tan IIA in combination with imatinib (IM) on the proliferation, apoptosis, migration and invasion of acute T lymp...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7453
更新日期:2020-02-01 00:00:00
abstract::The thioredoxin (Trx) system is an important enzymatic complex involved in cellular redox homeostasis. Arsenic trioxide (ATO; As2O3) is known to trigger cell death in vascular smooth muscle cells (VSMCs) via oxidative stress. In the present study, the effects of changes in thioredoxin 1 (Trx1) and Trx reductase1 (TrxR...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7414
更新日期:2020-01-01 00:00:00
abstract::Esophageal squamous cell carcinoma (ESCC) is a common type of esophageal cancer and is prevalent worldwide. Understanding the mechanisms underlying its formation and the search for more effective therapeutic strategies are critical due to the occurrence of chemotherapeutic drug resistance. The aim of the present study...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7395
更新日期:2020-01-01 00:00:00
abstract::MicroRNAs (miRNAs/miRs) in exosomes play crucial roles in the onset, progression and metastasis of cancer by regulating the stability of target mRNAs or by inhibiting translation. In the present study, differentially expressed miRNAs were identified in exosomes of 27 breast cancer patients and 3 healthy controls using...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7401
更新日期:2020-01-01 00:00:00
abstract::Subsequently to the publication of this paper, the authors have realized that the affilitation address omitted the name of the university at which this research was conducted (Capital Medical University). Therefore, the author affiliations for this paper should have appeared as follows (changes are highlighted in bold...
journal_title:Oncology reports
pub_type: 杂志文章,已发布勘误
doi:10.3892/or.2019.7385
更新日期:2019-12-01 00:00:00
abstract::A novel core‑shell type thermo‑nanoparticle (CSTNP) co‑loaded with temozolomide (TMZ) and the fluorescein new indocyanine green dye IR820 (termed IT‑CSTNPs) was designed and combined with a near‑infrared (NIR) laser to realize its photothermal conversion. The IT‑CSTNPs were prepared using a two‑step synthesis method a...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7329
更新日期:2019-12-01 00:00:00
abstract::Single nucleotide polymorphisms (SNPs) are the most common genetic variation in mammalian cells with prognostic potential. Anillin‑actin binding protein (ANLN) has been identified as being involved in PI3K/PTEN signaling, which is critical in cell life/death control, and kinase insert domain receptor (KDR) encodes a k...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7332
更新日期:2019-12-01 00:00:00
abstract::In the present study, to evaluate the role of Ku80 in thyroid carcinoma (TC), 86 thyroid tissue samples from patients with a spectrum of thyroid disorders were examined for protein levels of Ku80, nuclear factor‑κB (NF‑κB) and RET/TC by immunohistochemistry. Furthermore, in TC cells, Ku80 mRNA was detected by reverse ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7348
更新日期:2019-12-01 00:00:00
abstract::After having carefully checked the original data of Fig. 3, the authors noted that the student in their research group had inadvertently selected incorrect images for the 10 and 20 µM lycorine experiments to show the effect of lycorine on the migration of HepG2 cells during the figure compilation process. The correcte...
journal_title:Oncology reports
pub_type: 杂志文章,已发布勘误
doi:10.3892/or.2019.7362
更新日期:2019-12-01 00:00:00
abstract::Ovarian cancer (OC) is a common cancer of the human genital system. Circular RNAs (circRNAs) play an important role in carcinogenesis and progression of various cancers. The present study aimed to clarify the expression profile and functions of circ‑FAM53B in the progression of OC and reveal its underlying mechanisms....
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7366
更新日期:2019-12-01 00:00:00
abstract::A previous study by our group suggested that testis expressed 10 (Tex10) contributes to tumor progression by promoting stem cell‑like features in hepatocellular carcinoma. However, the relevance of pluripotency factor Tex10 in esophageal squamous cell carcinoma (ESCC) has remained elusive. The objective of the present...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7376
更新日期:2019-12-01 00:00:00
abstract::DNA methylation plays an important role in the genesis and progression of tumor diseases. To identify new DNA methylation markers possibly associated with the clinical characteristics of renal cell carcinoma (RCC), we investigated loci in the sarcosine dehydrogenase (SARDH) gene. SARDH is involved in the metabolism of...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7305
更新日期:2019-11-01 00:00:00
abstract::The aim of the present study was to investigate the role of miR‑203a‑3p in colorectal cancer (CRC) and identify the target gene of microRNA (miR)‑203a‑3p. A total of 59 sets of cancer tissues and corresponding adjacent non‑tumor tissues were collected from CRC patients (aged 31‑78 years) between October 2016 and May 2...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7310
更新日期:2019-11-01 00:00:00
abstract::It has been demonstrated that microRNA‑192 (miR‑192) serves important roles in different cancer types, including breast cancer, prostate cancer and colorectal cancer. However, its biological role and function in breast cancer remains largely unknown. The present study aimed to determine the role of miR‑192 in breast c...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7298
更新日期:2019-11-01 00:00:00
abstract::The restricted expression of Wilms tumor 1 (WT1) and cyclin A1 (CCNA1) in normal tissues, as opposed to their abnormal expression in leukemia demonstrates the applicability of WT1 and CCNA1 as cancer antigens for immunotherapy, and as markers for prognosis and relapse. In this study, the WT1 and CCNA1 mRNA levels were...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7287
更新日期:2019-11-01 00:00:00
abstract::Gallbladder cancer (GBC) is a lethal aggressive malignant neoplasm of the biliary tract. Potential prognostic markers and therapeutic targets for this disease are urgently required. Cancer‑associated fibroblasts (CAFs) play a key role in tumorigenesis and the development of cancer. Nicotinamide adenine dinucleotide ph...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7249
更新日期:2019-10-01 00:00:00
abstract::Carboxypeptidase X, M14 family member 2 (CPXM2), has been associated with several human disorders such as developmental diseases. However, whether CPXM2 is involved in oncogenesis or tumor progression remains unclear. In the present study, we used clinical samples from gastric cancer (GC) patients to investigate poten...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7254
更新日期:2019-10-01 00:00:00
abstract::The expression of CDR1‑AS, a representative circular RNA, is closely linked with poor prognosis in gastrointestinal cancers, such as colon, liver, and pancreatic cancers. Although it is well known that CDR1‑AS antagonizes microRNA‑7 function through its sequence similarities in the brain, its biological function and l...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7244
更新日期:2019-10-01 00:00:00
abstract::Long non‑coding RNAs (lncRNAs) can act as carcinogenic or cancer suppressive factors during the pathogenesis, invasion and metastasis of non‑small cell lung cancer (NSCLC). The current study explored the role of long intergenic non‑protein coding RNA 00887 (LINC00887) and competing endogenous RNAs (ceRNAs). It was rev...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7228
更新日期:2019-09-01 00:00:00
abstract::Signal transducer and activator of transcription 3 (STAT3) plays a key role in the transformation of normal cells to cancerous cells. Although inhibitors of STAT3 have been shown to suppress the growth of multiple cancer types in vitro and in vivo, such agents are of particular interest for the prevention of breast ca...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7219
更新日期:2019-09-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is sexually disparate in humans, with a significantly increased prevalence in males. The molecular mechanisms by which the inhibition or development of liver cancer are facilitated require further investigation with regard to sex factors affecting disease progression. In the present stud...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7217
更新日期:2019-09-01 00:00:00
abstract::Acute pancreatitis (AP) is an inflammatory disease with high morbidity and mortality rates. Pancreatic ductal cells are the most susceptible of all cell types that are exposed to the noxious stimuli of pancreatitis. Our previous studies demonstrated that emodin, a natural product extracted from Rheum palmatum L., prot...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7270
更新日期:2019-08-08 00:00:00
abstract::Glioblastoma multiforme (GBM) is the most malignant intracranial tumor. Although the affected patients are usually treated with surgery combined with radiotherapy and chemotherapy, the median survival time for GBM patients is still approximately 12‑14 months. Identifying the key molecular mechanisms and targets of GBM...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7204
更新日期:2019-08-01 00:00:00
abstract::Currently, various types of keratins have been reported to be highly expressed in cancer cells and to be associated with a malignant phenotype. In the present study, it was found that expression levels of keratin 6 (K6), keratin 16 (K16), and keratin 17 (K17) were highly elevated in SNU601 cells resistant to cisplatin...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7201
更新日期:2019-08-01 00:00:00
abstract::IncRNAs play an important role in the regulation of gene expression. The present study profiled differentially expressed lncRNAs (DELs) and mRNAs (DEMs) in myelodysplastic syndrome (MDS) to construct a 4‑aminobutyrate aminotransferase (ABAT)‑DEL‑DEM co‑expression network in MDS development using the Agilent human Bead...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7175
更新日期:2019-08-01 00:00:00
abstract::Gastric cancer (GC) is a severe public health problem worldwide, particularly in China. Radiotherapy is the main locoregional treatment for various types of unresectable tumor, including GC. However, many patients fail to respond to radiotherapy due to the intrinsic radioresistance of cancer cells. This study was desi...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7187
更新日期:2019-08-01 00:00:00
abstract::Large‑scale projects, such as The Cancer Genome Atlas (TCGA), Human Epigenome Project (HEP) and Human Epigenome Atlas (HEA), provide an insight into DNA methylation and histone modification markers. Changes in the epigenome significantly contribute to the initiation and progression of cancer. The goal of the present s...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7159
更新日期:2019-07-01 00:00:00
abstract::The present study aimed to investigate the role of miR‑181a in multiple myeloma (MM) cell lines. Reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) was used to detect the expression of microRNA (miR)‑181a. The MM cell line RPMI 8226 stably transduced with miR‑181a mimics or inhibitor was establishe...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7160
更新日期:2019-07-01 00:00:00
abstract::MicroRNA‑21 (miR‑21) is a potential therapeutic target for melanoma. Whether miR‑21 inhibitor affects the anti‑cancer activity of doxorubicin assisted by c(RGDyK)‑modified liposome (DLN) in melanoma and the underlying mechanisms are largely unknown. In this study, in vitro and animal models were used to explore the ef...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7167
更新日期:2019-07-01 00:00:00
abstract::Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase and mutations in this gene are major drivers of lung cancer development. EGFR tyrosine kinase inhibitors (TKIs) are standard first‑line therapies for patients with advanced non‑small cell lung cancer (NSCLC) with activating EGFR mutations, but are n...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7140
更新日期:2019-07-01 00:00:00
abstract::Histamine receptor H3 (HRH3) is mainly expressed in the central nervous system, where it is involved in the regulation of the release of various neurotransmitters in the brain. Recent studies have demonstrated that the expression of HRH3 is upregulated in several types of cancer. However, the functional effect of HRH3...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7119
更新日期:2019-06-01 00:00:00
abstract::Aberrantly expressed miRNAs play a crucial role in the progression of lung adenocarcinoma. However, to date, the role of miR‑888 in lung adenocarcinoma progression is unclear. In the present study, the biological function of miR‑888 and its underlying mechanism in lung adenocarcinoma progression were explored. RT‑qPCR...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7118
更新日期:2019-06-01 00:00:00